Acute respiratory distress syndrome is a complex group of signs and symptoms caused by direct or indirect lung injury. In spite of decades of research, it is still associated with a high mortality rate. Pathogenesis of this disease is related to alveolar endothelial and epithelial cell injury and associated release and sequestration of inflammatory mediators and cells, including cytokines and neutrophils, respectively. Pharmacologic interventions have been largely unsuccessful, and ventilation strategies to support oxygenation while limiting ventilator associated lung injury have not demonstrated any significant reductions in the mortality rate. However, novel therapies are in development, based on the knowledge of the pathologic processes of acute respiratory distress syndrome. In this article an overview of the disease process and mediator involvement is presented, followed by a review of pharmacologic and ventilation treatments currently in use or under study.
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Pathophysiology| May 01 2000
Pathophysiology and Implications for Treatment of Acute Respiratory Distress Syndrome
Mary H. van Soeren, RN, PhD, ACNP;
*From St. Joseph’s Health Centre and School of Nursing, University of Western Ontario, London, Ontario, Canada
Reprint requests to M. H. van Soeren, NP/CNS ICU, St. Joseph’s Health Centre, 268 Grosvenor Street, London, ON, Canada N6A 4V2; e-mail: firstname.lastname@example.org.
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William L. Diehl-Jones, PhD;
Robert J. Maykut, MD, FRCPC;
AACN Adv Crit Care (2000) 11 (2): 179–334.
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Mary H. van Soeren, William L. Diehl-Jones, Robert J. Maykut, Wael M. R. Haddara; Pathophysiology and Implications for Treatment of Acute Respiratory Distress Syndrome. AACN Adv Crit Care 1 May 2000; 11 (2): 179–334. doi:
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