Concurrent administration of medications and nutrients can lead to interactions that change the absorption or metabolism of the medication or nutrient. Some of these interactions have little or no impact on the patient while others may be fatal. The objective of this article is to review the mechanisms of various drug-nutrient interactions. Topics to be discussed include specific populations at risk of interactions, nutrients that have a positive and negative effect on drug absorption, nutrients that result in alterations of drug metabolism, and a variety of pharmacologic interactions of medications with nutrients. It is vital that healthcare providers are familiar with drug-nutrient interactions and continue to educate themselves and their patients to optimize the effectiveness and minimize the toxicities of medications.
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Nutrition| November 01 2000
Drug-Nutrient Interactions: A Review
Deborah A. Maka, PharmD;
From the Department of Pharmacy Services, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania.
Reprint requests to Deborah A. Maka, PharmD, Department of Pharmacy Services, The Children’s Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104.
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AACN Adv Crit Care (2000) 11 (4): 580–589.
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Deborah A. Maka, Laureen K. Murphy; Drug-Nutrient Interactions: A Review. AACN Adv Crit Care 1 November 2000; 11 (4): 580–589. doi:
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