Evidence-based practice rests on the knowledge generated from sound empirical research combined with clinical expertise. However, many clinicians lack the time to evaluate multiple studies. Meta-analysis is a statistical procedure for combining the results of multiple studies investigating a common problem or issue to produce a pooled effect size, and to evaluate the efficacy of interventions across studies. Meta-analysis can thus be used to synthesize and integrate empirical research to provide important evidence for best-practice decisions. This article examines the meta-analysis process and its links to evidence-based practice.