A myriad of novel mediators in neoplastic development and progression are currently being explored. Of significance are those that directly explain clinical manifestations of cancer, because understanding these may lead to new diagnostic, preventive, and therapeutic strategies. This review focuses on novel mediators that address how cancer, before it is treated, can induce cachexia, pain, hematological, and immune alterations. It highlights two concepts: first, that a synergy between tumor and stromal cells may be partly responsible for these manifestations, and second, that soluble factors, and in particular cytokines are being identified as major players in tumor-induced local and systemic effects.
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Biological Mediators| January 01 2004
Insights Into Novel Biological Mediators of Clinical Manifestations in Cancer
Otto H. Sanchez, MD, MSc, PhD
From the University of Ontario Institute of Technology, School of Health Sciences, Oshawa, Ontario, Canada.
Reprint requests to: Otto H. Sanchez, MD, MSc, PhD, Associate Professor, School of Health Sciences, University of Ontario Institute of Technology, 2000 Simcoe St North, Oshawa, Ontario, Canada L1H 7K4 (firstname.lastname@example.org).
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AACN Adv Crit Care (2004) 15 (1): 112–118.
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Otto H. Sanchez; Insights Into Novel Biological Mediators of Clinical Manifestations in Cancer. AACN Adv Crit Care 1 January 2004; 15 (1): 112–118. doi:
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