Technology in the digital age is rapidly ushering in a new era of evidence for clinical decision-making intended to overcome some of the challenges associated with current evidence-based practice (EBP). This issue of Technology Today highlights some of these issues as well as opportunities associated with practice-based evidence (PBE). PBE involves the electronic collection, aggregation, and analysis of clinical data for the purpose of augmenting or automating decision-making and achieving optimal health outcomes. Unlike EBP, PBE includes analyses of accessible data from all patients, all actual or potential diagnoses and comorbid conditions, all variations in treatments and interventions, and all variables and confounders captured in an electronic database or warehouse such as the electronic health record (EHR). PBE affords the real-world view of health, illness, and health care versus a controlled experiment and the shortcomings that are associated with that.

EBP is...

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