Drug therapy for dissolution of formed clots is a first-line approach in the treatment of myocardial infarction and thrombotic stroke. In addition, drug therapy for inhibition of the intrinsic and extrinsic pathways in the blood clotting cascade is used widely in ambulatory, acute care, and intensive care settings. Many health care providers mistakenly view these therapeutic approaches as identical. The authors review the physiology of intrinsic and extrinsic pathways in the blood clotting cascade and present the essential differences between anticoagulant and thrombolytic therapies
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Critical Care Potpourri| February 01 1994
Anticoagulants and Thrombolytics: What’s the Difference?
M. Linda Workman, RN, PHD, FAAN, OCN
From the Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio.
Reprint requests to M. Linda Workman, RN, PhD, FAAN, OCN, Associate Professor of Nursing, Frances Payne Bolton School of Nursing, Case Western Reserve University, 10900 Euclid Ave., Cleveland, OH 44106-4904.
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AACN Adv Crit Care (1994) 5 (1): 26–35.
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M. Linda Workman; Anticoagulants and Thrombolytics: What’s the Difference?. AACN Adv Crit Care 1 February 1994; 5 (1): 26–35. doi:
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