The Leukocyte Count, A Measure and Predictor of Coronary Events

Simplistic laboratory tests that are initially and routinely ordered by clinicians evaluating diseases are often unappreciated simply because they are routine. Resurrection of the leukocyte count is presented as a prime example of a sensitive measure and a prognostic indicator of acute myocardial infarction (MI) heretofore not given adequate coverage.

1.    c. inflammation

Cardiovascular disease is the leading cause of death in the Western world, and the most insidious form is atherosclerosis.¹ Although the risk factors for CHD have been identified, they do not explain the basis for the disease. Inflammation is a significant risk factor and key in the development of CV events. The relationship of inflammation to atherosclerosis has been established, that is, monocyte recruitment from peripheral blood into the vessel wall after endothelial injury, accumulation of inflammatory cells in the lipid plaque, neovascularization of adventitia...