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Cases of Note| September 01 2011

Levels of Neutrophil Gelatinase-Associated Lipocalin in 2 Patients With Crush Syndrome After a Mudslide

Valentina Donato, MD;

Valentina Donato, MD

Valentina Donato, Antonio Lacquaniti, Davide Bolignano, and Michele Buemi all work in the section of nephrology in the Department of Internal Medicine at the University of Messina in Messina, Italy. Alberto Noto, Antonio Versaci, Antonio David, and Francesco Spinelli all work in the intensive care unit of the Cardiothoracic and Vascular Department at the University of Messina

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Alberto Noto, MD;

Alberto Noto, MD

Valentina Donato, Antonio Lacquaniti, Davide Bolignano, and Michele Buemi all work in the section of nephrology in the Department of Internal Medicine at the University of Messina in Messina, Italy. Alberto Noto, Antonio Versaci, Antonio David, and Francesco Spinelli all work in the intensive care unit of the Cardiothoracic and Vascular Department at the University of Messina

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Antonio Lacquaniti, MD;

Antonio Lacquaniti, MD

Valentina Donato, Antonio Lacquaniti, Davide Bolignano, and Michele Buemi all work in the section of nephrology in the Department of Internal Medicine at the University of Messina in Messina, Italy. Alberto Noto, Antonio Versaci, Antonio David, and Francesco Spinelli all work in the intensive care unit of the Cardiothoracic and Vascular Department at the University of Messina

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Davide Bolignano, MD;

Davide Bolignano, MD

Valentina Donato, Antonio Lacquaniti, Davide Bolignano, and Michele Buemi all work in the section of nephrology in the Department of Internal Medicine at the University of Messina in Messina, Italy. Alberto Noto, Antonio Versaci, Antonio David, and Francesco Spinelli all work in the intensive care unit of the Cardiothoracic and Vascular Department at the University of Messina

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Antonio Versaci, MD;

Antonio Versaci, MD

Valentina Donato, Antonio Lacquaniti, Davide Bolignano, and Michele Buemi all work in the section of nephrology in the Department of Internal Medicine at the University of Messina in Messina, Italy. Alberto Noto, Antonio Versaci, Antonio David, and Francesco Spinelli all work in the intensive care unit of the Cardiothoracic and Vascular Department at the University of Messina

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Antonio David, MD;

Antonio David, MD

Valentina Donato, Antonio Lacquaniti, Davide Bolignano, and Michele Buemi all work in the section of nephrology in the Department of Internal Medicine at the University of Messina in Messina, Italy. Alberto Noto, Antonio Versaci, Antonio David, and Francesco Spinelli all work in the intensive care unit of the Cardiothoracic and Vascular Department at the University of Messina

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Francesco Spinelli, MD;

Francesco Spinelli, MD

Valentina Donato, Antonio Lacquaniti, Davide Bolignano, and Michele Buemi all work in the section of nephrology in the Department of Internal Medicine at the University of Messina in Messina, Italy. Alberto Noto, Antonio Versaci, Antonio David, and Francesco Spinelli all work in the intensive care unit of the Cardiothoracic and Vascular Department at the University of Messina

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Michele Buemi, MD

Michele Buemi, MD

Valentina Donato, Antonio Lacquaniti, Davide Bolignano, and Michele Buemi all work in the section of nephrology in the Department of Internal Medicine at the University of Messina in Messina, Italy. Alberto Noto, Antonio Versaci, Antonio David, and Francesco Spinelli all work in the intensive care unit of the Cardiothoracic and Vascular Department at the University of Messina

Corresponding author: Prof. Michele Buemi, Via salita Villa Contino 30, 98100 Messina, Italy (e-mail: buemim@unime.it).

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Am J Crit Care (2011) 20 (5): 405–409.

https://doi.org/10.4037/ajcc2011824

Neutrophil gelatinase-associated lipocalin is one of the most promising biomarkers for the diagnosis of acute kidney injury. An increase in the level of neutrophil gelatinase-associated lipocalin is a good predictor of acute kidney injury and is associated with an increase in the serum level of creatinine. Two victims of a mudslide in Messina, Italy, initially had crush syndrome followed by development of acute kidney injury. The development of acute kidney injury is the second most common cause of death after large earthquakes and other natural disasters, but at the same time, crush-related acute kidney injury is one of the few life-threatening complications of crush injuries that can be reversed if diagnosed early and treated. In this case, measuring the level of neutrophil gelatinase-associated lipocalin enabled early diagnosis of acute kidney injury and anticipation of the changes in levels of conventional markers such as creatinine.

©2011 American Association of Critical-Care Nurses

2011

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