About 4 million cases of pediatric/neonatal sepsis occur globally each year, resulting in significant morbidity and mortality. The World Health Organization has prioritized innovative research in sepsis management. Monitoring the inadequate oxygen delivery (IDo2) index as a predictor of adverse events is an emerging area of interest that has primarily been used in pediatric cardiac surgery but not with children with sepsis.

Roy and colleagues evaluated the relationship between IDo2 dose (mean IDo2 index during a specified time interval) and major adverse events (MAEs) in children admitted to the pediatric intensive care unit (PICU) with sepsis or septic shock. They found

  • Children with MAEs had significantly higher IDo2 doses over multiple time intervals than did children without MAEs.

  • Significant positive correlations between the IDo2 dose for 0 to 12 hours from admission and day 2 vasoactive-inotropic scores, organ dysfunction scores, PICU length of stay,...

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