Oxygen, a mainstay treatment for hypoxemia, is one of the most frequently used therapies for hospitalized patients. Overuse of oxygen may contribute to hyperoxemia, which clinicians may commonly disregard. However, hyperoxemia can cause pulmonary toxicity, disrupt antioxidant function, and strain the cardiovascular system. Similarly, excessive administration of oxygen (EAO) can impair mucociliary transport if not adequately humidified and heated, and high fractions of inspired oxygen contribute to absorption atelectasis, tracheobronchitis, and immunosuppression. Although hyperoxemia is linked to poor clinical outcomes in specific clinical situations (eg, septic shock and acute myocardial infarction), the evidence is conflicting among critically ill patients. Some studies and systematic reviews report an association between hyperoxemia and mortality, whereas others, including randomized clinical trials, show no significant differences in outcomes, leading to uncertainty about the overall impact of EAO on patient survival. Therefore, the authors of the present study sought to determine the prevalence of oxygen therapy–induced...

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