HUS is a complex multisystem disease. Research has increased our understanding of etiologic factors, presenting symptoms, lab findings, and course of the disease and has had an impact on treatment plans. As children present to community hospitals with symptomatology of dehydration, more careful analysis of electrolytes, BUN, creatinine, and hematologic smears have supported earlier diagnosis and directly impacted the morbidity and mortality of HUS. Astute ongoing nursing assessment and care in the critical care unit are crucial to promoting a favorable outcome.

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