This disease is incurable; treatment is focused on improving patients’ signs and symptoms and decreasing complications.

Hypertrophic obstructive cardiomyopathy (HOCM) is a genetically transmitted disease that affects approximately 0.2% to 4% of the US population.11 It is the result of a mutation in multiple genes that encode protein in the cardiac sarcomere, the primary contractile unit of the cardiac muscle.22 HOCM is typically inherited in an autosomal manner, with variable penetrance and variable expressivity.33 Approximately half of all cases of HOCM have an autosomal dominant pattern; the rest are the result of sporadic gene mutations.33,44 Recently, HOCM was linked to the cardiac myosin heavy-chain genes on chromosome 14 in some families, suggesting genetic heterogeneity.55 The age at which clinical manifestations become apparent varies. The existence of...

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