Prostacyclins are a high-risk category of continuous intravenous infusions increasingly used in hospitals to treat advanced pulmonary arterial hypertension, a rare condition characterized by vasoconstriction and vascular proliferation of the pulmonary arteries. Prostacyclins are given in doses of nanograms per kilogram per minute and have a narrow therapeutic dosing range for each patient. Sudden increases or decreases in dose can be life threatening. Previous studies revealed errors in the administration of these high-risk infusions, which in some instances led to serious adverse events, including death. The literature was reviewed for safety measures in administration of high-risk intravenous medications and input was obtained from leading experts in pulmonary arterial hypertension to create a set of safety recommendations for infusion of prostacyclins.
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Features| October 01 2013
Safety Recommendations for Administering Intravenous Prostacyclins in the Hospital
Martha S. Kingman, DNP, FNP-C;
Martha S. Kingman is a nurse practitioner in the pulmonary hypertension program at University of Texas Southwestern Medical Center, Dallas, Texas.
Corresponding author: Martha S. Kingman, dnp, fnp-c, University of Texas Southwestern Medical Center at Dallas, 5939 Harry Hines Blvd, Suite 600, Dallas, TX 75390 (e-mail: firstname.lastname@example.org).
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Crit Care Nurse (2013) 33 (5): 32–39.
Martha S. Kingman, Kelly Chin; Safety Recommendations for Administering Intravenous Prostacyclins in the Hospital. Crit Care Nurse 1 October 2013; 33 (5): 32–39. doi: https://doi.org/10.4037/ccn2013608
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