Intravenous lipid emulsion is an accepted therapy for the treatment of severe cardiac toxic effects caused by local anesthetics. Lipid emulsion therapy has also been used successfully to treat cardiac arrest and intractable arrhythmias caused by overdoses of antiepileptic drugs, cardiovascular drugs, and psychotropic medications, but experience with intravenous lipids as antidotal therapy in these clinical situations is limited. However, intravenous lipids are relatively safe, widely available, and easy to administer, and many published case reports document their dramatic effectiveness. Patients who have not responded to standard therapies have been quickly revived by administration of intravenous lipids. Use of lipids most likely will increase, and critical care nurses should be familiar with lipid therapy.
Columns| October 01 2014
Intravenous Lipids: Antidotal Therapy for Drug Overdose and Toxic Effects of Local Anesthetics
Dana Bartlett, RN, BSN, MSN, MA, CSPI
Dana Bartlett is a certified specialist in poison information at the Connecticut Poison Control Center, Farmington, Connecticut.
Corresponding author: Dana Bartlett, 180 Horseplain Rd, #A-3, New Britain, CT 06053 (e-mail: firstname.lastname@example.org).
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Crit Care Nurse (2014) 34 (5): 62–66.
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Dana Bartlett; Intravenous Lipids: Antidotal Therapy for Drug Overdose and Toxic Effects of Local Anesthetics. Crit Care Nurse 1 October 2014; 34 (5): 62–66. doi: https://doi.org/10.4037/ccn2014755
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