The present study has confirmed the findings of other research and indicates that current technology permits accurate CO determination using room temperature injectate. Some patients, especially those with high output, temperature, or blood pressure, may continue to require iced injectate measures to ensure accuracy; more research is needed here. Room temperature measures may be less reproducible than iced. Several ways of compensating for this have been suggested, depending on the technology available. At present, these methods are preferable to using a correction formula based on regression analyses.